Brain-Specific Inactivation of the Crhr1 Gene Inhibits Post-Dependent and Stress-Induced Alcohol Intake, but Does Not Affect Relapse-Like Drinking

Corticotropin-releasing hormone (CRH) and its receptor, CRH receptor-1 (CRHR1), have a key role in alcoholism. Especially, post-dependent and stress-induced alcohol intake involve CRH/CRHR1 signaling within extra-hypothalamic structures, but a contribution of the hypothalamic–pituitary–adrenal (HPA)...

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Detalhes bibliográficos
Main Authors: Molander, Anna, Vengeliene, Valentina, Heilig, Markus, Wurst, Wolfgang, Deussing, Jan M, Spanagel, Rainer
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280644/
https://ncbi.nlm.nih.gov/pubmed/22113086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2011.297
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