Acamprosate suppresses magnetic resonance spectroscopy measures of central glutamate in detoxified alcoholics: A randomized controlled experimental medicine study

CONTEXT: Acamprosate is approved for treatment of alcoholism, but its mechanism of action remains unclear. Animal studies suggest that a persistent hyperglutamatergic state contributes to the pathophysiology of alcoholism, and that acamprosate may exert its actions by intervening in this process. Hu...

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Главные авторы: Umhau, John C., Momenan, Reza, Schwandt, Melanie L., Singley, Erick, Lifshitz, Mariel, Doty, Linda, Adams, Lauren J., Vengeliene, Valentina, Spanagel, Rainer, Zhang, Yan, Shen, Jun, George, David T., Hommer, Daniel, Heilig, Markus
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583213/
https://ncbi.nlm.nih.gov/pubmed/20921123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archgenpsychiatry.2010.125
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