TGF-β1–Containing Exosomes from Injured Epithelial Cells Activate Fibroblasts to Initiate Tissue Regenerative Responses and Fibrosis

Hypoxia is associated with tissue injury and fibrosis but its functional role in fibroblast activation and tissue repair/regeneration is unknown. Using kidney injury as a model system, we demonstrate that injured epithelial cells produce an increased number of exosomes with defined genetic informati...

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Bibliographische Detailangaben
Hauptverfasser: Borges, Fernanda T., Melo, Sonia A., Özdemir, Berna C., Kato, Noritoshi, Revuelta, Ignacio, Miller, Caroline A., Gattone, Vincent H., LeBleu, Valerie S., Kalluri, Raghu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Nephrology 2013
Schlagworte:
Brief Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582210/
https://ncbi.nlm.nih.gov/pubmed/23274427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012101031
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