Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity

The Stimulator of Interferon Genes (STING) pathway is implicated in the innate immune response and is important in both oncogenesis and cancer treatment. Specifically, activation of the cytosolic DNA sensor STING in antigen-presenting cells (APCs) induces a type I interferon response and cytokine pr...

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Udgivet i:J Biol Chem
Main Authors: McAndrews, Kathleen M., Che, Sara P.Y., LeBleu, Valerie S., Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8042450/
https://ncbi.nlm.nih.gov/pubmed/33711340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100523
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