Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic Kras(G12D) in pancreatic cancer

CRISPR/Cas9 is a promising technology for gene editing. To date, intracellular delivery vehicles for CRISPR/Cas9 are limited by issues of immunogenicity, restricted packaging capacity, and low tolerance. Here, we report an alternative, nonviral delivery system for CRISPR/Cas9 based on engineered exo...

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Publicat a:Life Sci Alliance
Autors principals: McAndrews, Kathleen M, Xiao, Fei, Chronopoulos, Antonios, LeBleu, Valerie S, Kugeratski, Fernanda G, Kalluri, Raghu
Format: Artigo
Idioma:Inglês
Publicat: Life Science Alliance LLC 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321670/
https://ncbi.nlm.nih.gov/pubmed/34282051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.202000875
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