Adeno-associated virus capsid antigen presentation is dependent on endosomal escape

Adeno-associated virus (AAV) vectors are attractive for gene delivery-based therapeutics, but data from recent clinical trials have indicated that AAV capsids induce a cytotoxic T lymphocyte (CTL) response that eliminates transduced cells. In this study, we used traditional pharmacological agents an...

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Bibliographische Detailangaben
Hauptverfasser: Li, Chengwen, He, Yi, Nicolson, Sarah, Hirsch, Matt, Weinberg, Marc S., Zhang, Ping, Kafri, Tal, Samulski, R. Jude
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582142/
https://ncbi.nlm.nih.gov/pubmed/23454772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66611
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