Efficient Capsid Antigen Presentation From Adeno-Associated Virus Empty Virions In Vivo

Adeno-associated virus (AAV) vectors have been successfully applied in clinical trials for hemophilic patients. Although promising, the clinical results suggest that the capsid-specific CD8+T cell response has a negative effect on therapeutic success. In an in vitro analysis using an engineered AAV...

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Bibliografske podrobnosti
izdano v:Front Immunol
Main Authors: Pei, Xiaolei, Earley, Lauriel Freya, He, Yi, Chen, Xiaojing, Hall, Nikita Elexa, Samulski, Richard Jude, Li, Chengwen
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2018
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5916967/
https://ncbi.nlm.nih.gov/pubmed/29725339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00844
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