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AAV8 Virions Hijack Serum Proteins to Increase Hepatocyte Binding for Transduction Enhancement

It has been demonstrated that human serum albumin (HSA) directly interacts with AAV virions and enhances AAV transduction. Several other proteins have also been identified a potential for enhancing AAV8 liver transduction. In our study, LDL or transferrin could enhance transduction in vitro and in v...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Pei, Xiaolei, He, Ting, Hall, Nikita E., Gerber, David, Samulski, R. Jude, Li, Chengwen
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5911186/
https://ncbi.nlm.nih.gov/pubmed/29455066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.02.007
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