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Adeno-associated virus capsid antigen presentation is dependent on endosomal escape
Adeno-associated virus (AAV) vectors are attractive for gene delivery-based therapeutics, but data from recent clinical trials have indicated that AAV capsids induce a cytotoxic T lymphocyte (CTL) response that eliminates transduced cells. In this study, we used traditional pharmacological agents an...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582142/ https://ncbi.nlm.nih.gov/pubmed/23454772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66611 |
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