Kinetics of Adeno-Associated Virus Serotype 2 (AAV2) and AAV8 Capsid Antigen Presentation In Vivo Are Identical

Adeno-associated viral (AAV) vectors 2 and 8 have been used in clinical trials for patients with hemophilia, and data suggest that the capsid-specific CD8(+) T cell response has had a negative impact on therapeutic success. To date the pattern of capsid cross-presentation from AAV2 and AAV8 transduc...

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Main Authors: He, Yi, Weinberg, Marc S., Hirsch, Matt, Johnson, Mark C., Tisch, Roland, Samulski, R. Jude, Li, Chengwen
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655625/
https://ncbi.nlm.nih.gov/pubmed/23534873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2013.065
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