Cross-Packaging of a Single Adeno-Associated Virus (AAV) Type 2 Vector Genome into Multiple AAV Serotypes Enables Transduction with Broad Specificity

The serotypes of adeno-associated virus (AAV) have the potential to become important resources for clinical gene therapy. In an effort to compare the role of serotype-specific virion shells on vector transduction, we cloned each of the serotype capsid coding domains into a common vector backbone con...

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Autores principales: Rabinowitz, Joseph E., Rolling, Fabienne, Li, Chengwen, Conrath, Hervè, Xiao, Weidong, Xiao, Xiao, Samulski, R. Jude
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2002
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC136844/
https://ncbi.nlm.nih.gov/pubmed/11752169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.2.791-801.2002
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