Cancer regression and neurologic toxicity following anti-MAGE-A3 TCR gene therapy

Nine cancer patients were treated with adoptive cell therapy using autologous anti-MAGE-A3 TCR engineered T cells. Five patients experienced clinical regression of their cancers including two on-going responders. Beginning 1–2 days post-infusion, three patients (#’s 5, 7, and 8) experienced mental s...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Morgan, Richard A., Chinnasamy, Nachimuthu, Abate-Daga, Daniel D, Gros, Alena, Robbins, Paul F., Zheng, Zhili, Feldman, Steven A., Yang, James C., Sherry, Richard M., Phan, Giao Q., Hughes, Marybeth S., Kammula, Udai S., Miller, Akemi D., Hessman, Crystal J., Stewart, Ashley A., Restifo, Nicholas P., Quezado, Martha M., Alimchandani, Meghna, Rosenberg, Avi Z., Nath, Avindra, Wang, Tongguang, Bielekova, Bibiana, Wuest, Simone C., Nirmala, Akula, McMahon, Francis J., Wilde, Susanne, Mosetter, Barbara, Schendel, Dolores J., Laurencot, Carolyn M., Rosenberg, Steven A
التنسيق: Artigo
اللغة:Inglês
منشور في: 2013
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581823/
https://ncbi.nlm.nih.gov/pubmed/23377668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182829903
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