Cancer regression and neurologic toxicity following anti-MAGE-A3 TCR gene therapy

Nine cancer patients were treated with adoptive cell therapy using autologous anti-MAGE-A3 TCR engineered T cells. Five patients experienced clinical regression of their cancers including two on-going responders. Beginning 1–2 days post-infusion, three patients (#’s 5, 7, and 8) experienced mental s...

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Main Authors: Morgan, Richard A., Chinnasamy, Nachimuthu, Abate-Daga, Daniel D, Gros, Alena, Robbins, Paul F., Zheng, Zhili, Feldman, Steven A., Yang, James C., Sherry, Richard M., Phan, Giao Q., Hughes, Marybeth S., Kammula, Udai S., Miller, Akemi D., Hessman, Crystal J., Stewart, Ashley A., Restifo, Nicholas P., Quezado, Martha M., Alimchandani, Meghna, Rosenberg, Avi Z., Nath, Avindra, Wang, Tongguang, Bielekova, Bibiana, Wuest, Simone C., Nirmala, Akula, McMahon, Francis J., Wilde, Susanne, Mosetter, Barbara, Schendel, Dolores J., Laurencot, Carolyn M., Rosenberg, Steven A
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581823/
https://ncbi.nlm.nih.gov/pubmed/23377668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3182829903
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