A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer

Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid toxicity to normal tissues, we targeted cancer testis Ag (CTA) MAGE-A3, which is widely expressed in a range of epithelial m...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Chinnasamy, Nachimuthu, Wargo, Jennifer A., Yu, Zhiya, Rao, Mahadev, Frankel, Timothy L., Riley, John P., Hong, Jenny J., Parkhurst, Maria R., Feldman, Steven A., Schrump, David S., Restifo, Nicholas P., Robbins, Paul F., Rosenberg, Steven A., Morgan, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292200/
https://ncbi.nlm.nih.gov/pubmed/21149604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001775
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