A TCR Targeting the HLA-A*0201–Restricted Epitope of MAGE-A3 Recognizes Multiple Epitopes of the MAGE-A Antigen Superfamily in Several Types of Cancer

Adoptive immunotherapy using TCR-engineered PBLs against melanocyte differentiation Ags mediates objective tumor regression but is associated with on-target toxicity. To avoid toxicity to normal tissues, we targeted cancer testis Ag (CTA) MAGE-A3, which is widely expressed in a range of epithelial m...

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Bibliographic Details
Published in:J Immunol
Main Authors: Chinnasamy, Nachimuthu, Wargo, Jennifer A., Yu, Zhiya, Rao, Mahadev, Frankel, Timothy L., Riley, John P., Hong, Jenny J., Parkhurst, Maria R., Feldman, Steven A., Schrump, David S., Restifo, Nicholas P., Robbins, Paul F., Rosenberg, Steven A., Morgan, Richard A.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6292200/
https://ncbi.nlm.nih.gov/pubmed/21149604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1001775
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