Lys(48)-linked TAK1 polyubiquitination at lysine-72 downregulates TNFα-induced NF-κB activation via mediating TAK1 degradation

Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular processes. TAK1, a member of the MAPKKK family, is essential for TNFα-induced NF-κB activation. Phosphorylation and Lys(63)-linked polyubiquitination (polyUb) of TAK1 ar...

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Autores principales: Fan, Yihui, Shi, Yi, Liu, Shangfeng, Mao, Renfang, An, Lei, Zhao, Yanling, Zhang, Hong, Zhang, Fuchun, Xu, Guotong, Qin, Jun, Yang, Jianhua
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3580185/
https://ncbi.nlm.nih.gov/pubmed/22406003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2012.02.017
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