Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities

[Image: see text] Cancer cells often have a high demand for antiapoptotic proteins in order to resist programmed cell death. CDK9 inhibition selectively targets survival proteins and reinstates apoptosis in cancer cells. We designed a series of 4-thiazol-2-anilinopyrimidine derivatives with function...

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Hauptverfasser: Shao, Hao, Shi, Shenhua, Huang, Shiliang, Hole, Alison J., Abbas, Abdullahi Y., Baumli, Sonja, Liu, Xiangrui, Lam, Frankie, Foley, David W., Fischer, Peter M., Noble, Martin, Endicott, Jane A., Pepper, Chris, Wang, Shudong
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579313/
https://ncbi.nlm.nih.gov/pubmed/23301767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301475f
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