NKT associated Hedgehog and Osteopontin drive fibrogenesis in nonalcoholic fatty liver disease

Immune responses are important in dictating nonalcoholic steatohepatitis (NASH) outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN) occurs in NASH, that Hh-regulated accumulation of natural killer T (NKT) cells promotes hepatic stellate cell (HSC) activation, and...

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Autori principali: Syn, Wing-Kin, Agboola, Kola M, Swiderska, Marzena, Michelotti, Gregory, Liaskou, Evaggelia, Pang, Herbert, Xie, Guanhua, Philips, George, Chan, Isaac S, Karaca, Gamze F, Pereira, Thiago A, Chen, Yuping, Mi, Zhiyong, Kuo, Paul C, Choi, Steve S, Guy, Cynthia D, Abdelmalek, Manal F, Diehl, Anna Mae
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578424/
https://ncbi.nlm.nih.gov/pubmed/22427237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301857
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