NKT associated Hedgehog and Osteopontin drive fibrogenesis in nonalcoholic fatty liver disease

Immune responses are important in dictating nonalcoholic steatohepatitis (NASH) outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN) occurs in NASH, that Hh-regulated accumulation of natural killer T (NKT) cells promotes hepatic stellate cell (HSC) activation, and...

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Autors principals: Syn, Wing-Kin, Agboola, Kola M, Swiderska, Marzena, Michelotti, Gregory, Liaskou, Evaggelia, Pang, Herbert, Xie, Guanhua, Philips, George, Chan, Isaac S, Karaca, Gamze F, Pereira, Thiago A, Chen, Yuping, Mi, Zhiyong, Kuo, Paul C, Choi, Steve S, Guy, Cynthia D, Abdelmalek, Manal F, Diehl, Anna Mae
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578424/
https://ncbi.nlm.nih.gov/pubmed/22427237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301857
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