Paracrine Hedgehog Signaling Drives Metabolic Changes in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) typically develop in cirrhosis, a condition characterized by Hedgehog (Hh) pathway activation and accumulation of Hh-responsive myofibroblasts (MF). Although Hh signaling generally regulates stromal-epithelial interactions that support epithelial viability, the role of...

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Autors principals: Chan, Isaac S., Guy, Cynthia D., Chen, Yuping, Lu, Jiuyi, Swiderska, Marzena, Michelotti, Gregory A., Karaca, Gamze, Xie, Guanhua, Krüger, Leandi, Syn, Wing-Kin, Anderson, Blair R., Pereira, Thiago A., Choi, Steve S., Baldwin, Albert S., Diehl, Anna Mae
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3525764/
https://ncbi.nlm.nih.gov/pubmed/23066040
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1068
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