NKT associated Hedgehog and Osteopontin drive fibrogenesis in nonalcoholic fatty liver disease

Immune responses are important in dictating nonalcoholic steatohepatitis (NASH) outcome. We previously reported that upregulation of hedgehog (Hh) and osteopontin (OPN) occurs in NASH, that Hh-regulated accumulation of natural killer T (NKT) cells promotes hepatic stellate cell (HSC) activation, and...

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Detalhes bibliográficos
Main Authors: Syn, Wing-Kin, Agboola, Kola M, Swiderska, Marzena, Michelotti, Gregory, Liaskou, Evaggelia, Pang, Herbert, Xie, Guanhua, Philips, George, Chan, Isaac S, Karaca, Gamze F, Pereira, Thiago A, Chen, Yuping, Mi, Zhiyong, Kuo, Paul C, Choi, Steve S, Guy, Cynthia D, Abdelmalek, Manal F, Diehl, Anna Mae
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578424/
https://ncbi.nlm.nih.gov/pubmed/22427237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2011-301857
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