NMR solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing

The most potent tumorigen identified among the polycyclic aromatic hydrocarbons (PAH) is the non-planar fjord region dibenzo[a,l]pyrene (DB[a,l]P). It is metabolically activated in vivo through the widely-studied diol epoxide (DE) pathway to form covalent adducts with DNA bases, predominantly guanin...

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Detalhes bibliográficos
Main Authors: Tang, Yijin, Liu, Zhi, Ding, Shuang, Lin, Chin H., Cai, Yuqin, Rodriguez, Fabian A., Sayer, Jane M., Jerina, Donald M., Amin, Shantu, Broyde, Suse, Geacintov, Nicholas E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578312/
https://ncbi.nlm.nih.gov/pubmed/23121427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi3013577
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