Methylation of Cytosine at C5 in a CpG Sequence Context Causes a Conformational Switch of a Benzo[a]pyrene diol epoxide-N(2)-guanine Adduct in DNA from a Minor Groove Alignment to Intercalation with Base Displacement

It is well known that CpG dinucleotide steps in DNA, which are highly methylated at the 5-position of cytosine (meC) in human tissues, exhibit a disproportionate number of mutations within certain codons of the p53 gene. There is ample published evidence indicating that the reactivity of guanine wit...

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Publicado no:J Mol Biol
Main Authors: Zhang, Na, Lin, Chin, Huang, Xuanwei, Kolbanovskiy, Aleksandr, Hingerty, Brian E., Amin, Shantu, Broyde, Suse, Geacintov, Nicholas E., Patel, Dinshaw J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4694590/
https://ncbi.nlm.nih.gov/pubmed/15701509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2004.12.027
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