Methylation of Cytosine at C5 in a CpG Sequence Context Causes a Conformational Switch of a Benzo[a]pyrene diol epoxide-N(2)-guanine Adduct in DNA from a Minor Groove Alignment to Intercalation with Base Displacement

Eitemau Tebyg

• Exocyclic amino groups of flanking guanines govern sequence-dependent adduct conformations and local structural distortions for minor groove-aligned benzo[a]pyrenyl-guanine lesions in a GG mutation hotspot context
  gan: Rodríguez, Fabián A., et al.
  Cyhoeddwyd: (2007)
• Solution conformation of the major adduct between the carcinogen (+)-anti-benzo[a]pyrene diol epoxide and DNA.
  gan: Cosman, M, et al.
  Cyhoeddwyd: (1992)
• Adenine-DNA adducts derived from the highly tumorigenic dibenzo[a,l]pyrene are resistant to nucleotide excision repair while guanine adducts are not
  gan: Kropachev, Konstantin, et al.
  Cyhoeddwyd: (2013)
• NMR solution structure of an N(2)-guanine DNA adduct derived from the potent tumorigen dibenzo[a,l]pyrene: Intercalation from the minor groove with ruptured Watson-Crick base pairing
  gan: Tang, Yijin, et al.
  Cyhoeddwyd: (2012)
• Base pair conformation-dependent excision of benzo[a]pyrene diol epoxide-guanine adducts by human nucleotide excision repair enzymes.
  gan: Hess, M T, et al.
  Cyhoeddwyd: (1997)