Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2

Estrogen receptor-α (ERα) is crucial for the adaptive response of bone to loading but the role of endogenous estradiol (E2) for this response is unclear. To determine in vivo the ligand dependency and relative roles of different ERα domains for the osteogenic response to mechanical loading, gene-tar...

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Detalhes bibliográficos
Main Authors: Windahl, Sara H, Saxon, Leanne, Börjesson, Anna E, Lagerquist, Marie K, Frenkel, Baruch, Henning, Petra, Lerner, Ulf H, Galea, Gabriel L, Meakin, Lee B, Engdahl, Cecilia, Sjögren, Klara, Antal, Maria C, Krust, Andrée, Chambon, Pierre, Lanyon, Lance E, Price, Joanna S, Ohlsson, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575695/
https://ncbi.nlm.nih.gov/pubmed/22972752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1754
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