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SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice
The bone-sparing effect of estrogens is mediated primarily via estrogen receptor (ER)α, which stimulates gene transcription through activation function (AF)-1 and AF-2. The role of ERαAF-1 for the estradiol (E(2)) effects is tissue specific. The selective ER modulators (SERMs) raloxifene (Ral), laso...
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Publicado no: | Am J Physiol Endocrinol Metab |
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Main Authors: | , , , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4935145/ https://ncbi.nlm.nih.gov/pubmed/27048997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00488.2015 |
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