SERMs have substance-specific effects on bone, and these effects are mediated via ERαAF-1 in female mice

The bone-sparing effect of estrogens is mediated primarily via estrogen receptor (ER)α, which stimulates gene transcription through activation function (AF)-1 and AF-2. The role of ERαAF-1 for the estradiol (E(2)) effects is tissue specific. The selective ER modulators (SERMs) raloxifene (Ral), laso...

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Publicado en:Am J Physiol Endocrinol Metab
Autores principales: Börjesson, Anna E., Farman, Helen H., Movérare-Skrtic, Sofia, Engdahl, Cecilia, Antal, Maria Cristina, Koskela, Antti, Tuukkanen, Juha, Carlsten, Hans, Krust, Andrée, Chambon, Pierre, Sjögren, Klara, Lagerquist, Marie K., Windahl, Sara H., Ohlsson, Claes
Formato: Artigo
Lenguaje:Inglês
Publicado: American Physiological Society 2016
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4935145/
https://ncbi.nlm.nih.gov/pubmed/27048997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00488.2015
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