Estrogen receptor-α in osteocytes is important for trabecular bone formation in male mice

The bone-sparing effect of estrogen in both males and females is primarily mediated via estrogen receptor-α (ERα), encoded by the Esr1 gene. ERα in osteoclasts is crucial for the trabecular bone-sparing effect of estrogen in females, but it is dispensable for trabecular bone in male mice and for cor...

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Main Authors: Windahl, Sara H., Börjesson, Anna E., Farman, Helen H., Engdahl, Cecilia, Movérare-Skrtic, Sofia, Sjögren, Klara, Lagerquist, Marie K., Kindblom, Jenny M., Koskela, Antti, Tuukkanen, Juha, Divieti Pajevic, Paola, Feng, Jian Q., Dahlman-Wright, Karin, Antonson, Per, Gustafsson, Jan-Åke, Ohlsson, Claes
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568324/
https://ncbi.nlm.nih.gov/pubmed/23345419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220811110
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