The estrogen receptor antagonist ICI 182,780 can act both as an agonist and an inverse agonist when estrogen receptor α AF-2 is modified

The bone-sparing effect of estrogen is primarily mediated via estrogen receptor (ER) α, which stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal and AF-2 in the ligand-binding domain. It was recently demonstrated that the ER antagonist ICI 182,780 (IC...

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Detalhes bibliográficos
Main Authors: Movérare-Skrtic, Sofia, Börjesson, Anna E., Farman, Helen H., Sjögren, Klara, Windahl, Sara H., Lagerquist, Marie K., Andersson, Annica, Stubelius, Alexandra, Carlsten, Hans, Gustafsson, Jan-Åke, Ohlsson, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3903248/
https://ncbi.nlm.nih.gov/pubmed/24395795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1322910111
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