Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...

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Dades bibliogràfiques
Publicat a:J Endocrinol
Autors principals: Funck-Brentano, Thomas, Nilsson, Karin H, Brommage, Robert, Henning, Petra, Lerner, Ulf H, Koskela, Antti, Tuukkanen, Juha, Cohen-Solal, Martine, Movérare-Skrtic, Sofia, Ohlsson, Claes
Format: Artigo
Idioma:Inglês
Publicat: Bioscientifica Ltd 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987170/
https://ncbi.nlm.nih.gov/pubmed/29720540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-18-0153
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