Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...

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Détails bibliographiques
Publié dans:J Endocrinol
Auteurs principaux: Funck-Brentano, Thomas, Nilsson, Karin H, Brommage, Robert, Henning, Petra, Lerner, Ulf H, Koskela, Antti, Tuukkanen, Juha, Cohen-Solal, Martine, Movérare-Skrtic, Sofia, Ohlsson, Claes
Format: Artigo
Langue:Inglês
Publié: Bioscientifica Ltd 2018
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987170/
https://ncbi.nlm.nih.gov/pubmed/29720540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-18-0153
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