Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice

WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Endocrinol
Main Authors: Funck-Brentano, Thomas, Nilsson, Karin H, Brommage, Robert, Henning, Petra, Lerner, Ulf H, Koskela, Antti, Tuukkanen, Juha, Cohen-Solal, Martine, Movérare-Skrtic, Sofia, Ohlsson, Claes
Format: Artigo
Jezik:Inglês
Izdano: Bioscientifica Ltd 2018
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987170/
https://ncbi.nlm.nih.gov/pubmed/29720540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-18-0153
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