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Porcupine inhibitors impair trabecular and cortical bone mass and strength in mice
WNT signaling is involved in the tumorigenesis of various cancers and regulates bone homeostasis. Palmitoleoylation of WNTs by Porcupine is required for WNT activity. Porcupine inhibitors are under development for cancer therapy. As the possible side effects of Porcupine inhibitors on bone health ar...
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| Veröffentlicht in: | J Endocrinol |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Bioscientifica Ltd
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5987170/ https://ncbi.nlm.nih.gov/pubmed/29720540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/JOE-18-0153 |
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