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The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice
High estradiol levels in late puberty induce growth plate closure and thereby cessation of growth in humans. In mice, the growth plates do not fuse after sexual maturation, but old mice display reduced longitudinal bone growth and high-dose estradiol treatment induces growth plate closure. Estrogen...
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Main Authors: | , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Physiological Society
2012
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3378067/ https://ncbi.nlm.nih.gov/pubmed/22414805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00646.2011 |
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