The role of estrogen receptor-α and its activation function-1 for growth plate closure in female mice

High estradiol levels in late puberty induce growth plate closure and thereby cessation of growth in humans. In mice, the growth plates do not fuse after sexual maturation, but old mice display reduced longitudinal bone growth and high-dose estradiol treatment induces growth plate closure. Estrogen...

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Hauptverfasser: Börjesson, A. E., Windahl, S. H., Karimian, E., Eriksson, E. E., Lagerquist, M. K., Engdahl, C., Antal, M. C., Krust, A., Chambon, P., Sävendahl, L., Ohlsson, C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2012
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378067/
https://ncbi.nlm.nih.gov/pubmed/22414805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00646.2011
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