Roles of transactivating functions 1 and 2 of estrogen receptor-α in bone

The bone-sparing effect of estrogen is primarily mediated via estrogen receptor-α (ERα), which stimulates target gene transcription through two activation functions (AFs), AF-1 in the N-terminal and AF-2 in the ligand binding domain. To evaluate the role of ERα AF-1 and ERα AF-2 for the effects of e...

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Main Authors: Börjesson, A. E., Windahl, S. H., Lagerquist, M. K., Engdahl, C., Frenkel, B., Movérare-Skrtic, S., Sjögren, K., Kindblom, J. M., Stubelius, A., Islander, U., Antal, M. C., Krust, A., Chambon, P., Ohlsson, C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3076831/
https://ncbi.nlm.nih.gov/pubmed/21444817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100454108
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