Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts

The ATR-dependent intra-S checkpoint protects DNA replication forks undergoing replication stress. The checkpoint is enforced by ATR-dependent phosphorylation of CHK1, which is mediated by the TIMELESS-TIPIN complex and CLASPIN. Although loss of checkpoint proteins is associated with spontaneous chr...

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Main Authors: Smith-Roe, Stephanie L., Patel, Shivani S., Zhou, Yingchun, Simpson, Dennis A., Rao, Shangbang, Ibrahim, Joseph G., Cordeiro-Stone, Marila, Kaufmann, William K.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575462/
https://ncbi.nlm.nih.gov/pubmed/23255133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23177
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