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Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts
The ATR-dependent intra-S checkpoint protects DNA replication forks undergoing replication stress. The checkpoint is enforced by ATR-dependent phosphorylation of CHK1, which is mediated by the TIMELESS-TIPIN complex and CLASPIN. Although loss of checkpoint proteins is associated with spontaneous chr...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Landes Bioscience
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3575462/ https://ncbi.nlm.nih.gov/pubmed/23255133 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23177 |
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