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The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement

UV-induced DNA damage stalls DNA replication forks and activates the intra-S checkpoint to inhibit replicon initiation. In response to stalled replication forks, ATR phosphorylates and activates the transducer kinase Chk1 through interactions with the mediator proteins TopBP1, Claspin, and Timeless...

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Autori principali: Ünsal-Kaçmaz, Keziban, Chastain, Paul D., Qu, Ping-Ping, Minoo, Parviz, Cordeiro-Stone, Marila, Sancar, Aziz, Kaufmann, William K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2007
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899931/
https://ncbi.nlm.nih.gov/pubmed/17296725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.02190-06
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