Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?

The ATR/CHK1-dependent intra-S checkpoint inhibits replicon initiation and replication fork progression in response to DNA damage caused by UV (UV) radiation. It has been proposed that this signaling cascade protects against UV-induced mutations by reducing the probability that damaged DNA will be r...

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Autores principales: Sproul, Christopher D, Rao, Shangbang, Ibrahim, Joseph G, Kaufmann, William K, Cordeiro-Stone, Marila
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906341/
https://ncbi.nlm.nih.gov/pubmed/24091629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26590
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