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Is activation of the intra-S checkpoint in human fibroblasts an important factor in protection against UV-induced mutagenesis?
The ATR/CHK1-dependent intra-S checkpoint inhibits replicon initiation and replication fork progression in response to DNA damage caused by UV (UV) radiation. It has been proposed that this signaling cascade protects against UV-induced mutations by reducing the probability that damaged DNA will be r...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Landes Bioscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3906341/ https://ncbi.nlm.nih.gov/pubmed/24091629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.26590 |
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