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The role of protein tyrosine phosphatase 1B in Ras signaling
Protein tyrosine phosphatase (PTP) 1B has been implicated as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases. Inhibition of this enzyme was initially thought to potentially lead to increased oncogenic signaling and tumorigenesis. Surprisingly, we show that...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC357013/ https://ncbi.nlm.nih.gov/pubmed/14766979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304242101 |
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