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Shp-2 Tyrosine Phosphatase Functions as a Negative Regulator of the Interferon-Stimulated Jak/STAT Pathway

Shp-2 is an SH2 domain-containing protein tyrosine phosphatase. Although the mechanism remains to be defined, substantial experimental data suggest that Shp-2 is primarily a positive regulator in cell growth and development. We present evidence here that Shp-2, while acting to promote mitogenic sign...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Principais autores: You, Min, Yu, De-Hua, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC84034/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10022928/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.19.3.2416
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