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The role of protein tyrosine phosphatase 1B in Ras signaling

Protein tyrosine phosphatase (PTP) 1B has been implicated as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases. Inhibition of this enzyme was initially thought to potentially lead to increased oncogenic signaling and tumorigenesis. Surprisingly, we show that...

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Detalhes bibliográficos
Main Authors: Dubé, Nadia, Cheng, Alan, Tremblay, Michel L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC357013/
https://ncbi.nlm.nih.gov/pubmed/14766979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304242101
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