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The role of protein tyrosine phosphatase 1B in Ras signaling

Protein tyrosine phosphatase (PTP) 1B has been implicated as a negative regulator of multiple signaling pathways downstream of receptor tyrosine kinases. Inhibition of this enzyme was initially thought to potentially lead to increased oncogenic signaling and tumorigenesis. Surprisingly, we show that...

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Autores principales: Dubé, Nadia, Cheng, Alan, Tremblay, Michel L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC357013/
https://ncbi.nlm.nih.gov/pubmed/14766979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304242101
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