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The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Abstract Background Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an essential mediator of pro- and anti-inflammatory processes. Dysregulat...

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Principais autores: Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper, Anna Dittrich
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-09-01
Serier:Cell Communication and Signaling
Fag:
Signal transduction
SHP2
PTPN11
JAK/STAT
MAPK
Information theory
Online adgang:https://doi.org/10.1186/s12964-021-00770-7
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