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Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways

Gene expression is regulated by DNA as well as histone modifications but the crosstalk and mechanistic link between these epigenetic signals are still poorly understood. Here we investigate the multi-domain protein Uhrf2 that is similar to Uhrf1, an essential cofactor of maintenance DNA methylation....

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Detalhes bibliográficos
Main Authors: Pichler, Garwin, Wolf, Patricia, Schmidt, Christine S, Meilinger, Daniela, Schneider, Katrin, Frauer, Carina, Fellinger, Karin, Rottach, Andrea, Leonhardt, Heinrich
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3569875/
https://ncbi.nlm.nih.gov/pubmed/21598301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.23185
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