Potent Mechanism-Based Inactivation Of Cytochrome P450 2B4 By 9-Ethynylphenanthrene: Implications For Allosteric Modulation Of Cytochrome P450 Catalysis()

The mechanism-based inactivation of cytochrome P450 2B4 (CYP2B4) by 9-ethynylphenanthrene (9EP) has been investigated. The partition ratio and k(inact) are 0.2 and 0.25 min(−1), respectively. Intriguingly, the inactivation exhibits sigmoidal kinetics with a Hill coefficient of 2.5 and S(50) of 4.5 μ...

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Bibliographic Details
Main Authors:	Zhang, Haoming, Gay, Sean C., Shah, Manish, Foroozesh, Maryam, Liu, Jiawang, Osawa, Yoichi, Zhang, Qinghai, Stout, C. David, Halpert, James R., Hollenberg, Paul F.
Format:	Artigo
Language:	Inglês
Published:	2013
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3568706/ https://ncbi.nlm.nih.gov/pubmed/23276288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301567z
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Potent Mechanism-Based Inactivation Of Cytochrome P450 2B4 By 9-Ethynylphenanthrene: Implications For Allosteric Modulation Of Cytochrome P450 Catalysis()

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