Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase

Interactions of membrane-bound mammalian cytochromes P450 (CYPs) with NADPH-cytochrome P450 oxidoreductase (POR), which are required for metabolism of xenobiotics, are facilitated by membrane lipids. A variety of membrane mimetics, such as phospholipid liposomes and nanodiscs, have been used to simu...

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Vydáno v:J Biol Chem
Hlavní autoři: Cheng, Shen, Bo, Zhiyuan, Hollenberg, Paul, Osawa, Yoichi, Zhang, Haoming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2021
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8113742/
https://ncbi.nlm.nih.gov/pubmed/33839156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100645
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