Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

BACKGROUND: Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT). The chemokine receptor CCR5 appears to play a role in alloreactivity. We tested whether CCR5 blockade would be safe and limit GVHD in humans. METHODS: We tested th...

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Detalhes bibliográficos
Main Authors: Reshef, Ran, Luger, Selina M., Hexner, Elizabeth O., Loren, Alison W., Frey, Noelle V., Nasta, Sunita D., Goldstein, Steven C., Stadtmauer, Edward A., Smith, Jacqueline, Bailey, Sarah, Mick, Rosemarie, Heitjan, Daniel F., Emerson, Stephen G., Hoxie, James A., Vonderheide, Robert H., Porter, David
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568501/
https://ncbi.nlm.nih.gov/pubmed/22784116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1201248
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