Extended CCR5 Blockade for Graft-Versus-Host Disease Prophylaxis Improves Outcomes of Reduced Intensity Unrelated Donor Hematopoietic Cell Transplantation: A Phase II Clinical Trial

Graft-versus-host disease (GVHD) remains the most common treatment-related complication after allogeneic hematopoietic cell transplantation (allo-HCT). Lymphocyte migration plays a critical role in the pathogenesis of GVHD. A previous phase I/II trial demonstrated that CCR5 blockade with maraviroc i...

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Detalhes bibliográficos
Publicado no:Biol Blood Marrow Transplant
Main Authors: Reshef, Ran, Ganetsky, Alex, Acosta, Edward P., Blauser, Robin, Crisalli, Lisa, McGraw, Jessica, Frey, Noelle V., Hexner, Elizabeth O., Hoxie, James A., Loren, Alison W., Luger, Selina M., Mangan, James, Stadtmauer, Edward A., Mick, Rosemarie, Vonderheide, Robert H., Porter, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6445759/
https://ncbi.nlm.nih.gov/pubmed/30315941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2018.09.034
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