Blockade of Lymphocyte Chemotaxis in Visceral Graft-versus-Host Disease

BACKGROUND: Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic stem-cell transplantation (HSCT). The chemokine receptor CCR5 appears to play a role in alloreactivity. We tested whether CCR5 blockade would be safe and limit GVHD in humans. METHODS: We tested th...

Full description

Saved in:
Bibliographic Details
Main Authors: Reshef, Ran, Luger, Selina M., Hexner, Elizabeth O., Loren, Alison W., Frey, Noelle V., Nasta, Sunita D., Goldstein, Steven C., Stadtmauer, Edward A., Smith, Jacqueline, Bailey, Sarah, Mick, Rosemarie, Heitjan, Daniel F., Emerson, Stephen G., Hoxie, James A., Vonderheide, Robert H., Porter, David
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3568501/
https://ncbi.nlm.nih.gov/pubmed/22784116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1201248
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items