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Energy for Wild-Type Acetylcholine Receptor Channel Gating from Different Choline Derivatives

Agonists, including the neurotransmitter acetylcholine (ACh), bind at two sites in the neuromuscular ACh receptor channel (AChR) to promote a reversible, global change in protein conformation that regulates the flow of ions across the muscle cell membrane. In the synaptic cleft, ACh is hydrolyzed to...

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Bibliografiske detaljer
Main Authors: Bruhova, Iva, Gregg, Timothy, Auerbach, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566445/
https://ncbi.nlm.nih.gov/pubmed/23442907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.11.3833
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