Tricyclic Benzo[cd]azulenes Selectively Inhibit Activities of Pim Kinases and Restrict Growth of Epstein-Barr Virus-Transformed Cells

Oncogenic Pim family kinases are often overexpressed in human hematopoietic malignancies as well as in solid tumours. These kinases contribute to tumorigenesis by promoting cell survival and by enhancing resistance against chemotherapy and radiation therapy. Furthermore, we have recently shown that...

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Hauptverfasser: Kiriazis, Alexandros, Vahakoski, Riitta L., Santio, Niina M., Arnaudova, Ralica, Eerola, Sini K., Rainio, Eeva-Marja, Aumüller, Ingo B., Yli-Kauhaluoma, Jari, Koskinen, Päivi J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3566155/
https://ncbi.nlm.nih.gov/pubmed/23405147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055409
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